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4X"7-Ir;&_5Y0!%*L@s^I;JlT\E9qq@(]? Chronic otitis media (OM) is the most common cause of hearing loss worldwide, yet the underlying genetics and molecular pathology are poorly understood. In this respect, rats offer many, Cre transgenic mice can be used to delete gene sequences flanked by loxP sites in specific somatic tissues. These models have guided the therapeutic targeting of cancer-causing mutations and paved the way for assessing anti-cancer drug responses and the preclinical development of immunotherapies. [o
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-on6U;0c0Hp:#oF)Eb-$S0q!H/s.! A large collection of Cre transgenic lines has been generated over time and can be used in a combinatorial manner to achieve gene inactivation in many different cell types. !MRRi[qKljpBUM)apdtGq+WWf*QPiJ@?QE=uB&Qj:QRqnSHepYH]X3Q
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